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Ketamine has shown promise in the treatment of bipolar depression, a challenging condition characterized by depressive episodes alternating with periods of mania or hypomania. While traditional antidepressants can sometimes trigger manic episodes in individuals with bipolar disorder, ketamine's mechanism of action appears to be distinct, making it a potentially safer option. By modulating glutamate transmission, promoting synaptic plasticity, and reducing inflammation, ketamine may alleviate depressive symptoms without precipitating manic episodes. Its rapid onset of action is particularly beneficial for individuals experiencing acute depressive episodes, providing relief when conventional treatments may be ineffective or contraindicated. However, the use of ketamine in bipolar disorder requires careful monitoring and consideration of individual risk factors, including the potential for mood destabilization.